A cyber-physical system (CPS) is a mechanism that is controlled or monitored by computer-based algorithms, tightly integrated with the Internet and its users. In cyber-physical systems, physical and software components are deeply intertwined, each operating on different spatial and temporal scales, exhibiting multiple and distinct behavioral modalities, and interacting with each other in a myriad of ways that change with context. CPS mechanisms allow to obtain several application in the Smart Integration area, which includes New Product Development, Suppliers Relationship Management, Product Lifecycle Management, and Digital twin, that refers to a digital replica of physical assets, processes and systems that can be used for various purposes. The digital representation provides both the elements and the dynamics of how CPS device operates and lives throughout its life cycle.